Southern Cheesy Chicken Spaghetti Casserole

Southern Cheesy Chicken Spaghetti Casserole: Comfort Food at Its Best

There’s something truly comforting about a hearty casserole—especially one that’s packed with cheesy goodness, tender chicken, and satisfying pasta. If you’re looking for a dish that’s both family-friendly and bursting with flavor, Southern Cheesy Chicken Spaghetti Casserole is your go-to recipe. This rich, creamy casserole combines the classic flavors of Southern cooking into one mouthwatering meal that’s sure to please a crowd.

Perfect for weeknight dinners, potlucks, or cozy family gatherings, this casserole is not only easy to prepare but also incredibly versatile. Whether you’re making it ahead of time or assembling it on the spot, you’ll love how simple ingredients come together to create a dish that feels indulgent and comforting.

Why You’ll Love Southern Cheesy Chicken Spaghetti Casserole

Rich and Creamy: A cheesy, creamy sauce coats the chicken and pasta, making every bite melt-in-your-mouth delicious.
Quick and Easy: While it may taste like you spent hours in the kitchen, this casserole can be put together in about 15-20 minutes—perfect for busy nights.
Kid-Friendly: With its creamy cheese sauce and tender chicken, this dish is a hit with kids and adults alike.
Make-Ahead: This casserole can be prepared in advance, making it an ideal option for meal prepping or busy weeknights.
Leftovers: This casserole keeps well and reheats beautifully, so you can enjoy it for days after you’ve made it.

Ingredients for Southern Cheesy Chicken Spaghetti Casserole

For the Casserole:

2 cups cooked chicken (shredded or cubed; rotisserie chicken works great!)
8 oz spaghetti (broken into thirds)
1 can (10.5 oz) cream of chicken soup (or cream of mushroom soup)
1 can (10 oz) diced tomatoes with green chilies (like Rotel, optional for a little heat)
1 cup sour cream
2 cups shredded sharp cheddar cheese (you can use a mix of cheddar and mozzarella for a meltier result)
1/2 cup milk (or chicken broth for more flavor)
1/2 teaspoon garlic powder
1/2 teaspoon onion powder
Salt and pepper to taste
1 tablespoon butter (optional, for greasing the baking dish)
1/2 cup grated Parmesan cheese (for topping, optional)

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